Understanding how RAG endonuclease controls immune cell development
Elucidating Mechanisms of RAG Endonuclease Mediated Feedback Inhibition of V(D)J Recombination
This study is looking at how a specific enzyme helps control the process that makes our immune cells, like B and T cells, work properly, which is important for keeping our immune responses on target and preventing them from attacking our own bodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10870099 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which RAG endonuclease mediates feedback inhibition of V(D)J recombination, a crucial process in the development of B and T cells. By studying the role of the ATM kinase in this process, the research aims to uncover how the body ensures that immune responses are specific and prevents autoimmunity. The methodology involves examining genetic and molecular interactions in pre-B cells to understand how RAG-induced DNA breaks signal for the regulation of gene expression. This could lead to insights into immune system functioning and potential therapies for related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to immune system dysfunction, such as autoimmune diseases or genetic immunodeficiencies.
Not a fit: Patients with unrelated health conditions or those not affected by immune system disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of autoimmune diseases and immune deficiencies.
How similar studies have performed: Previous research has shown promising results in understanding the role of ATM in immune cell regulation, indicating that this approach has potential for significant findings.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Bassing, Craig H — Children's Hosp of Philadelphia
- Study coordinator: Bassing, Craig H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.