Understanding how radiation treatment affects cancer at a molecular level
Project 2: Transcriptional Dynamics and Temporal Reprogramming During Radiation Treatment
This study is looking at how radiation therapy affects cancer cells over time to help find better ways to treat cancer, so patients can have more personalized and effective care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10896485 on NIH RePORTER |
What this research studies
This research investigates the effects of radiation therapy on cancer cells, focusing on how these cells change over time during treatment. By analyzing the transcriptional dynamics, or the way genes are expressed, the study aims to uncover the biological mechanisms that influence the effectiveness of radiation therapy. The approach combines advanced genomic sequencing and bioinformatics to identify patterns that could lead to more personalized treatment strategies for cancer patients. Patients may benefit from insights that could improve the outcomes of their radiation therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are scheduled to receive radiation therapy as part of their treatment.
Not a fit: Patients who are not undergoing radiation therapy or those with non-cancerous conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized radiation treatment plans for cancer patients.
How similar studies have performed: Other research has shown promising results in understanding the molecular effects of radiation therapy, indicating that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Scott, Jacob Gardinier — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Scott, Jacob Gardinier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.