Understanding how radiation therapy affects thinking skills in glioma patients
Official title: Mechanisms of Radiation-Induced Neurocognitive Decline (MIND): Longitudinal Study of Imaging Biomarkers and Risk and Resilience Factors Underlying Cognitive Phenotypes in Patients with Glioma
Funded at University of California, San Diego · NIH-11047478 · Data updated 2026-11-12
This study is looking at how radiation therapy affects thinking and memory in people with glioma, and it aims to find ways to help protect brain function during treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | December 5, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $667,485 |
| NIH project number | 1R01CA289833-01A1 |
| Project ID | NIH-11047478 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are glioma patients who are undergoing radiation therapy and are 21 years or older.
✕Less likely to help
Patients with glioma who are not receiving radiation therapy may not benefit from this research.
What this research studies
This research investigates the cognitive decline that often occurs in glioma patients following radiation therapy. By using advanced imaging techniques and a patient-centered approach, the study aims to identify different cognitive profiles and the underlying mechanisms of this decline. It will also explore various risk and resilience factors that may influence cognitive outcomes. Patients will be monitored over time to better understand how radiation impacts brain function and to develop strategies for minimizing cognitive damage.
Why it matters
Potential benefit: If successful, this research could lead to improved radiation therapy techniques that preserve cognitive function in glioma patients.
How similar studies have gone: Previous research has shown promising results in understanding cognitive decline related to cancer treatments, but this study aims to explore new methodologies and insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Hattangadi-Gluth, Jona a — University of California, San Diego
- Study coordinator: Hattangadi-Gluth, Jona a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.