Understanding how radiation therapy affects the immune response in cervical cancer
Official title: METEOR-Comprehensive Radiobiology Assessment TRial (METEOR-CRATR)
Funded at Washington University · NIH-10912699 · Data updated 2026-11-12
This study is looking at how immune cells and tumors work together in patients with locally advanced cervical cancer who are receiving radiation and cisplatin, to help find ways to improve treatment and make it more effective for the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $59,098 |
| NIH project number | 5U54CA274318-02 |
| Project ID | NIH-10912699 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with locally advanced cervical cancer who are receiving radiation therapy and cisplatin.
✕Less likely to help
Patients with early-stage cervical cancer or those not undergoing radiation therapy may not benefit from this research.
What this research studies
This research investigates the interactions between immune cells and tumors in patients with locally advanced cervical cancer undergoing radiation therapy combined with cisplatin. By analyzing the tumor microenvironment, the study aims to understand how these treatments influence immune responses and contribute to treatment resistance. Patients will be involved in a molecular characterization trial that collects detailed clinical and biological data to improve future treatment strategies. The goal is to identify factors that may lead to better outcomes and reduce the failure rates associated with current therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance anti-tumor immunity and reduce recurrence rates in cervical cancer patients.
How similar studies have gone: Previous research has shown promising results in understanding tumor-immune interactions in other cancer types, suggesting potential for success in this novel approach.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Robinson, Clifford Grant — Washington University
- Study coordinator: Robinson, Clifford Grant
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.