Understanding how radiation harms blood-forming cells
Molecular modulators of radiation-induced chromosome instability and hematopoietic damage
This project looks for ways to protect the body's blood-forming system from damage caused by radiation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11118880 on NIH RePORTER |
What this research studies
Our blood-forming system, called the hematopoietic system, is very sensitive to radiation, which can cause both short-term and long-term harm. The ability to recover from bone marrow failure, whether from illness or medical treatments, depends on how resilient our blood stem cells are and how well the bone marrow environment supports them. We are exploring specific molecules that influence this recovery to find new ways to protect against radiation damage. This work focuses on how a molecule called Bccip affects the sensitivity of blood stem cells to radiation and their ability to rebuild the blood system.
Who could benefit from this research
Good fit: This foundational research does not currently involve direct patient participation, but future studies might seek individuals who have experienced radiation exposure or bone marrow issues.
Not a fit: Patients not at risk of radiation exposure or bone marrow damage would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new medicines that protect patients from radiation damage, especially to their bone marrow.
How similar studies have performed: Preliminary studies in mice have suggested that the molecule Bccip plays a role in radiation sensitivity and bone marrow recovery.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Shen, Zhiyuan — Rutgers Biomedical and Health Sciences
- Study coordinator: Shen, Zhiyuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.