Understanding how radiation exposure affects health through specific cellular mechanisms
Official title: Elucidating underlying mechanisms in RIPK2-mediated toxicity following exposure to radiation
Funded at Iowa City VA Medical Center · NIH-10798987 · Data updated 2026-11-12
This study is looking at how radiation can harm our health and how a specific protein called RIPK2 might play a role in making radiation sickness and cancer worse, with the hope of finding better treatments for people, like military personnel, who are at risk of radiation exposure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa City VA Medical Center NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 1I01BX006091-01A1 |
| Project ID | NIH-10798987 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include military personnel and individuals who have been exposed to high levels of radiation due to medical treatments or occupational hazards.
✕Less likely to help
Patients who have not been exposed to radiation or those with unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the harmful effects of radiation exposure on human health, particularly focusing on how certain cellular mechanisms contribute to radiation-induced illnesses. The study aims to explore the role of RIPK2, a protein that may influence the severity of acute radiation syndrome and cancer risk following radiation exposure. By using animal models, the researchers will analyze how the absence of RIPK2 affects the body's response to lethal doses of radiation, potentially leading to new therapies for those affected by radiation. The findings could provide insights into targeted treatments for military personnel and others at risk of radiation exposure.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect against or treat radiation-induced illnesses, improving outcomes for affected individuals.
How similar studies have gone: While the specific focus on RIPK2 in the context of radiation exposure is novel, previous research has shown success in understanding cellular responses to radiation, indicating potential for impactful findings.
Where this research is happening
-
Iowa City VA Medical Center
Iowa City, United States Active
Researchers
- Principal investigator: Gurung, Prajwal — Iowa City VA Medical Center
- Study coordinator: Gurung, Prajwal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.