Understanding how radiation affects the immune response in tumors
Predict radiation-induced shifts in patient-specific tumor immune ecosystem composition to harness immunological consequences of radiotherapy
This study is looking at how radiation therapy can help your immune system better fight cancer by changing the way your tumor interacts with immune cells, and it aims to find out the best radiation doses for improving your treatment outcomes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11077827 on NIH RePORTER |
What this research studies
This research investigates how radiation therapy can change the composition of the immune environment within tumors, potentially enhancing the body's ability to fight cancer. By analyzing the interactions between tumor cells and immune cells, the study aims to identify specific immune responses that can be triggered by different radiation doses. Patients' tumor-immune ecosystems will be modeled to predict how they might respond to radiation treatment, with the goal of improving therapeutic outcomes. The research combines laboratory experiments with clinical data to create a simulation framework that can guide personalized treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients undergoing radiation therapy who have a measurable immune response to their tumors.
Not a fit: Patients with tumors that do not elicit an immune response or those who are not receiving radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective radiation therapies that better harness the immune system to fight cancer.
How similar studies have performed: Previous research has shown promising results in enhancing immune responses through radiation therapy, indicating that this approach has potential for significant advancements in cancer treatment.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Enderling, Heiko — University of Tx Md Anderson Can Ctr
- Study coordinator: Enderling, Heiko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.