Understanding how radiation affects T cell immune function and metabolism
Metabolic impairment plays a critical role in radiation-induced T cell immune dysfunction
This study is looking at how exposure to radiation affects the immune system, especially how it changes T cells that help fight infections, to find ways to boost immunity for people who have been exposed to radiation.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11074637 on NIH RePORTER |
What this research studies
This research investigates the impact of ionizing radiation on T cell immunity, particularly focusing on how metabolic changes in T cells can lead to immune dysfunction. By studying a bacterial infection model, the researchers aim to understand the long-term effects of radiation exposure on T cell populations and their ability to respond to pathogens. The study will explore the metabolic pathways that are altered in T cells after radiation exposure, which may contribute to compromised immunity. This research could provide insights into improving immune responses in individuals affected by radiation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced radiation exposure, such as survivors of acute radiation syndrome.
Not a fit: Patients who have not been exposed to radiation or do not have T cell-related immune dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune function in patients who have been exposed to radiation.
How similar studies have performed: Previous research has shown that understanding the metabolic needs of immune cells can lead to significant advancements in treating immune dysfunction, suggesting that this approach has potential for success.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Fornace, Albert J — Georgetown University
- Study coordinator: Fornace, Albert J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.