Understanding how radiation affects prostate cancer cells to stop spread
Radiation modulation of cell plasticity programs determine prostate cancer oligometastatic potential
This work aims to understand how radiation treatment affects prostate cancer cells to prevent the cancer from spreading further in patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11171445 on NIH RePORTER |
What this research studies
Prostate cancer can spread to new areas, and this work explores how radiation might stop that process. We believe that cancer cells can change their properties, allowing them to travel and create new tumors, sometimes even returning to the original tumor site. This project looks at how focused radiation treatments might alter these cell changes, making it harder for cancer to spread. By understanding these cellular changes, we hope to find better ways to manage prostate cancer and improve patient outcomes.
Who could benefit from this research
Good fit: This foundational work is relevant to patients with prostate cancer, especially those with early signs of spread or at risk of metastasis.
Not a fit: Patients without prostate cancer or those whose cancer has already widely spread may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to more effective radiation strategies to prevent prostate cancer from spreading, potentially improving survival for patients.
How similar studies have performed: While the idea of consolidating all disease sites with radiation is supported by some studies, the specific question of how radiation impacts cell plasticity to impede metastasis is a novel area of exploration.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Tran, Phuoc T. — University of Maryland Baltimore
- Study coordinator: Tran, Phuoc T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.