Understanding how race affects the development of pancreatic cancer
Project 3 ADM
['FUNDING_OTHER'] · UNIVERSITY OF FLORIDA · NIH-10931541
This study is looking at how changes in the pancreas that can lead to pancreatic cancer happen differently in people from various racial backgrounds, especially focusing on why Black individuals might be at a higher risk, and it hopes to find ways to prevent this serious disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10931541 on ClinicalTrials.gov |
What this research studies
This research investigates the early processes that lead to pancreatic ductal adenocarcinoma (PDAC), particularly focusing on how acinar-to-ductal metaplasia (ADM) varies among different racial groups. By analyzing pancreatic tissues from Black, White, and Hispanic donors, the study aims to uncover the cellular and molecular mechanisms that contribute to the higher incidence of PDAC in Black populations. The research will also explore the role of chronic pancreatitis as a precursor to PDAC, providing insights into potential prevention strategies. Patients may benefit from a better understanding of how their race influences their risk for developing this aggressive cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from Black, White, and Hispanic backgrounds, especially those with a family history of pancreatic cancer or chronic pancreatitis.
Not a fit: Patients who do not belong to the racial groups being studied or those without risk factors for pancreatic cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted prevention strategies and treatments for pancreatic cancer, particularly for high-risk populations.
How similar studies have performed: Previous studies have shown that racial differences exist in the development of pancreatic cancer, suggesting that this research could build on established findings.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHMITTGEN, THOMAS D. — UNIVERSITY OF FLORIDA
- Study coordinator: SCHMITTGEN, THOMAS D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.