Understanding how R-spondin affects treatment response in colorectal cancer
Biology of R-Spondin-Induced Sensitization to Asparaginase in Colorectal Cancer
This study is looking at how a protein called R-spondin can help make colorectal cancer cells more responsive to a treatment called asparaginase, with the goal of finding new ways to help patients with colorectal cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11165575 on NIH RePORTER |
What this research studies
This research investigates how R-spondin, a protein involved in cell signaling, can make colorectal cancer cells more sensitive to a treatment called asparaginase. The researchers will use human colorectal cancer cell lines and genetically engineered mouse models to explore the mechanisms behind this sensitization. By understanding the relationship between Wnt signaling and asparaginase resistance, the study aims to identify new therapeutic strategies for patients with colorectal cancer. The approach involves genetic screening and analysis of protein degradation pathways to uncover potential vulnerabilities in cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer, especially those with specific genetic mutations related to Wnt signaling.
Not a fit: Patients with colorectal cancer who do not have R-spondin translocations or other relevant mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with colorectal cancer, particularly those who are resistant to current therapies.
How similar studies have performed: Previous research has shown that targeting Wnt signaling can create vulnerabilities in cancer cells, suggesting that this approach may hold promise for colorectal cancer treatment.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Gutierrez, Alejandro — St. Jude Children's Research Hospital
- Study coordinator: Gutierrez, Alejandro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.