Understanding how pulmonary vasodilator therapy affects heart function in patients with Fontan physiology
Mechanisms of Clinical and Hemodynamic Response to Pulmonary Vasodilator Therapy in Fontan physiology
This study is looking at how a special treatment for lung blood vessels can help people who have had the Fontan surgery for heart problems, especially to see if it makes it easier for them to exercise and feel better overall.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10992142 on NIH RePORTER |
What this research studies
This research investigates the effects of pulmonary vasodilator therapy on patients who have undergone the Fontan operation for congenital heart disease. It aims to understand the mechanisms behind the therapy's effectiveness, particularly in improving pulmonary vascular reserve during exercise. By assessing how these therapies impact heart function and overall health, the study seeks to establish better diagnostic criteria and treatment protocols for patients with complex heart conditions. The research involves clinical assessments and monitoring of patients' responses to the therapy over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone the Fontan operation and are experiencing pulmonary vascular disease.
Not a fit: Patients who have not had the Fontan operation or do not have pulmonary vascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance heart function and quality of life for patients with Fontan physiology.
How similar studies have performed: Previous research has shown varying success with pulmonary vasodilator therapies in similar patient populations, indicating that this area is both relevant and in need of further exploration.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Egbe, Alexander — Mayo Clinic Rochester
- Study coordinator: Egbe, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.