Understanding how pulmonary hypertension affects cognitive decline and Alzheimer's disease
Phenotypes and mechanisms of pulmonary hypertension-driven cognitive impairment and Alzheimer's disease
This study is looking at how pulmonary hypertension might affect thinking and memory, especially in people with Alzheimer's, by exploring how low oxygen levels and inflammation in the brain could lead to these problems, with the hope of finding new ways to help those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10498427 on NIH RePORTER |
What this research studies
This research investigates the relationship between pulmonary hypertension and cognitive impairment, particularly focusing on Alzheimer's disease. It employs both laboratory and animal models to explore how low oxygen levels and blood-brain barrier dysfunction contribute to the development of Alzheimer's symptoms. The study aims to identify specific mechanisms and phenotypes associated with cognitive decline in patients suffering from pulmonary hypertension. By examining the role of inflammatory cytokines and their effects on brain cells, the research seeks to uncover potential pathways for intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension who are experiencing cognitive impairment or are at risk for Alzheimer's disease.
Not a fit: Patients without pulmonary hypertension or those who do not exhibit cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline in patients with pulmonary hypertension.
How similar studies have performed: Previous research has indicated a link between pulmonary conditions and cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Cai, Hua Linda — University of California Los Angeles
- Study coordinator: Cai, Hua Linda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.