Understanding how pulmonary fibrosis progresses over time
Official title: Reconceptualizing Disease Progression in Pulmonary Fibrosis
Funded at Vanderbilt University Medical Center · NIH-11105662 · Data updated 2026-11-12
This study is looking at how pulmonary fibrosis, a serious lung disease, develops in people who have symptoms and in their family members who might be at risk, to help find ways to catch the disease early and improve treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $797,845 |
| NIH project number | 1R01HL179065-01 |
| Project ID | NIH-11105662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with pulmonary fibrosis and their asymptomatic relatives who may be at risk for the disease.
✕Less likely to help
Patients with other unrelated lung conditions or those who are not related to individuals with pulmonary fibrosis may not benefit from this research.
What this research studies
This research investigates the progression of pulmonary fibrosis, a serious lung disease, by examining both symptomatic patients and their asymptomatic relatives who are at risk of developing the condition. The study utilizes a registry to collect data on lung function over time, employing advanced statistical methods to analyze how disease progression varies among individuals. By focusing on early detection and understanding the timeline of lung function decline, the research aims to identify better endpoints for clinical trials and improve treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and earlier interventions for patients with pulmonary fibrosis.
How similar studies have gone: Previous research has shown promise in using similar approaches to understand disease progression in other chronic conditions, suggesting potential for success in this area as well.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Salisbury, Margaret Louise — Vanderbilt University Medical Center
- Study coordinator: Salisbury, Margaret Louise
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to progressive lung scarring
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Alveolar Cell Dysfunction in Pulmonary Fibrosis: Using SFTPC Mutations to Find New Targets
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Iron and scar-forming cells in the lungs (IPF)
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Screening new compounds to reverse gene signatures in IPF lungs
A researcher hopes to find compounds that reverse harmful gene changes in the lungs of people with idiopathic pulmonary fibrosis (IPF).
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Role of lactate transporters in lung scarring
Aims to see if blocking lactate transporters can slow or stop scar-forming cells from thickening the lungs in people with fibrotic lung disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.