Understanding how pulmonary arterial hypertension affects muscle mass
Unraveling the systemic manifestations of pulmonary arterial hypertension on lean muscle mass
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10859459
This study is looking at how pulmonary arterial hypertension (PAH) affects muscle mass in patients, aiming to find out who might have low muscle mass and why, so we can better understand how it impacts their health and daily life.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10859459 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of pulmonary arterial hypertension (PAH) on lean muscle mass, a critical aspect often overlooked in patients with this condition. By examining a group of PAH patients, the study aims to identify those with low muscle mass and explore the underlying metabolic factors contributing to this issue. The research will utilize advanced techniques to assess muscle composition and its relationship with overall health outcomes, including quality of life and physical activity levels. Patients will be evaluated for various factors, including body composition and the role of fat tissue in muscle loss.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension, particularly those experiencing symptoms related to muscle weakness or low lean mass.
Not a fit: Patients without a diagnosis of pulmonary arterial hypertension or those who do not exhibit issues with muscle mass may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of muscle loss in patients with pulmonary arterial hypertension, potentially enhancing their quality of life.
How similar studies have performed: Previous research has indicated that addressing muscle mass loss in chronic conditions can lead to significant improvements in patient outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AL-NAAMANI, NADINE — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: AL-NAAMANI, NADINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.