Understanding how PTEN mutant prostate cancer spreads
Metastasis of PTEN Mutant Prostate Cancer
['FUNDING_R01'] · COLD SPRING HARBOR LABORATORY · NIH-10912718
This study is looking at how a specific type of prostate cancer spreads and becomes harder to treat, with the goal of finding new ways to help men facing this serious condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLD SPRING HARBOR LABORATORY (nih funded) |
| Locations | 1 site (COLD SPRING HARBOR, UNITED STATES) |
| Trial ID | NIH-10912718 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the spread of PTEN mutant prostate cancer, which is a significant cause of mortality in men. By analyzing patient samples and using advanced imaging techniques, the study aims to identify genetic factors that contribute to the cancer's metastasis and resistance to treatment. The approach combines single-cell analysis and 3D imaging in genetically engineered mouse models to uncover critical pathways involved in the disease's progression. This could lead to new insights into how to better manage and treat metastatic prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with PTEN mutant prostate cancer, particularly those experiencing metastasis.
Not a fit: Patients with localized prostate cancer who do not have PTEN mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for metastatic prostate cancer, potentially increasing survival rates.
How similar studies have performed: Previous research has shown promising results in understanding cancer metastasis through genetic analysis and advanced imaging techniques, suggesting this approach could yield valuable insights.
Where this research is happening
COLD SPRING HARBOR, UNITED STATES
- COLD SPRING HARBOR LABORATORY — COLD SPRING HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TROTMAN, LLOYD C — COLD SPRING HARBOR LABORATORY
- Study coordinator: TROTMAN, LLOYD C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.