Understanding how PTEN affects brain inflammation after repeated mild injuries
Official title: THE ROLE OF PTEN IN MICROGLIAL PATHOBIOLOGY AFTER EXPOSURE TO REPETITIVE MILD TBI
Funded at Roskamp Institute, INC. · NIH-10683340 · Data updated 2026-11-12
This study is looking at how a protein called PTEN affects the brain's immune response after repeated mild brain injuries, using mice to help find ways to prevent long-term brain problems for people who have had similar injuries.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roskamp Institute, INC. NIH-funded |
| Lab location | 1 site (Sarasota, United States) |
| Project start | August 15, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $163,440 |
| NIH project number | 5R03AG078772-02 |
| Project ID | NIH-10683340 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced repetitive mild traumatic brain injuries, such as athletes or military personnel.
✕Less likely to help
Patients who have not experienced any form of traumatic brain injury may not benefit from this research.
What this research studies
This research investigates the role of a protein called PTEN in the brain's immune response following repetitive mild traumatic brain injuries (r-mTBI). Using a mouse model that mimics human brain injuries, the study aims to uncover the cellular mechanisms that lead to long-term neurological issues after such injuries. By analyzing gene profiles of brain immune cells (microglia) over time, the research seeks to identify potential therapeutic targets that could help prevent neurodegenerative diseases linked to r-mTBI.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or mitigate the long-term effects of brain injuries.
How similar studies have gone: Other research has shown promise in understanding neuroinflammation and its role in neurodegenerative diseases, making this approach both relevant and potentially impactful.
Where this research is happening
-
Roskamp Institute, INC.
Sarasota, United States Active
Researchers
- Principal investigator: Ojo, Joseph O — Roskamp Institute, INC.
- Study coordinator: Ojo, Joseph O
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.