Understanding how PSGL-1 affects HIV infection
Mechanisms of PSGL-1 restriction of HIV virion infectivity
This study is looking at a protein called PSGL-1 that might help keep HIV from spreading in the body, and it could lead to new ways to help people with HIV stay healthy for a long time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Mason University NIH-funded |
| Lab location | 1 site (Fairfax, United States) |
| Project ID | NIH-10812397 on NIH RePORTER |
What this research studies
This research investigates the role of PSGL-1, a protein found on certain immune cells, in limiting the infectivity of HIV. By examining how PSGL-1 interacts with HIV and its components, the study aims to uncover new mechanisms that could help in controlling or eliminating the virus from the body. The approach includes detailed laboratory experiments to analyze the binding and incorporation of PSGL-1 in HIV particles and its effects on the virus's ability to infect healthy cells. The findings could lead to innovative therapeutic strategies for achieving long-term remission in HIV patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are seeking new treatment options or those interested in contributing to innovative HIV research.
Not a fit: Patients who are not infected with HIV or those who are not interested in experimental treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help control or eliminate HIV, improving the quality of life for patients living with the virus.
How similar studies have performed: Other research has shown promise in targeting viral restriction factors, suggesting that this approach could lead to significant advancements in HIV treatment.
Where this research is happening
Fairfax, United States
- George Mason University — Fairfax, United States (Active)
Researchers
- Principal investigator: Wu, Yuntao — George Mason University
- Study coordinator: Wu, Yuntao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.