Understanding how Pseudomonas bacteria resist antibiotics
Official title: Regulation and mechanism of RND-mediated antibiotic efflux in Pseudomonas
Funded at Emory University · NIH-11110381 · Data updated 2026-11-12
This study is looking at how a common bacteria called Pseudomonas aeruginosa becomes resistant to antibiotics by using special proteins to push the medicine out, and it aims to find new ways to fight these tough infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | June 10, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $647,684 |
| NIH project number | 5R01AI185192-02 |
| Project ID | NIH-11110381 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant Pseudomonas aeruginosa.
✕Less likely to help
Patients with infections caused by bacteria other than Pseudomonas aeruginosa may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the bacteria Pseudomonas aeruginosa develops resistance to antibiotics, particularly focusing on a specific group of proteins known as RND efflux pumps. These pumps help the bacteria expel antibiotics, making infections harder to treat. The study aims to uncover how these pumps are regulated and how they select which antibiotics to expel, which could lead to new strategies for overcoming antibiotic resistance. By collaborating with a team of researchers, the project will utilize advanced techniques to analyze the structure and function of these efflux systems.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively combat antibiotic-resistant infections, improving outcomes for patients.
How similar studies have gone: Previous research has shown success in understanding antibiotic resistance mechanisms, but this specific approach to studying RND efflux pumps is relatively novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Dunham, Christine M — Emory University
- Study coordinator: Dunham, Christine M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.