Understanding how Pseudomonas aeruginosa uses heme to survive and cause infections
Mechanistic characterization and regulation of the non-redundant phu and has heme uptake systems of Pseudomonas aeruginosa
This study looks at how the bacteria Pseudomonas aeruginosa gets the iron it needs to grow, focusing on its special systems for using heme, which could help us find better ways to treat infections caused by this germ.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11225324 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the bacteria Pseudomonas aeruginosa acquires iron, specifically through its heme uptake systems. By utilizing bacterial genetics and biochemical analysis, the study aims to characterize the non-redundant roles of the heme assimilation (has) and Pseudomonas heme utilization (phu) systems in the bacteria's ability to sense and transport heme. The research also explores how these systems affect bacterial behavior, such as motility and biofilm formation, which are critical for infection. Patients may benefit from insights gained into how to combat infections caused by this opportunistic pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by Pseudomonas aeruginosa, particularly those with antibiotic-resistant strains.
Not a fit: Patients with infections caused by other types of bacteria that do not involve heme uptake mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating infections caused by antibiotic-resistant bacteria like Pseudomonas aeruginosa.
How similar studies have performed: Other research has shown success in targeting bacterial iron acquisition systems, indicating potential for breakthroughs in treating infections.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Wilks, Angela — University of Maryland Baltimore
- Study coordinator: Wilks, Angela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.