Understanding how Pseudomonas aeruginosa survives in the presence of nitric oxide.
Official title: Uncovering mechanisms of nitric oxide detoxification and reactivity in Pseudomonas aeruginosa
Funded at Rutgers, the State Univ of N.j. · NIH-10866077 · Data updated 2026-11-12
This study is looking at how a germ called Pseudomonas aeruginosa, which can cause serious infections, survives when your body's immune system tries to fight it off using a substance called nitric oxide; by understanding how this germ protects itself, researchers hope to find new ways to treat infections, especially those that are hard to treat with antibiotics.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | June 9, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $158,000 |
| NIH project number | 1K22AI182146-01 |
| Project ID | NIH-10866077 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with chronic infections caused by Pseudomonas aeruginosa, particularly those who are immunocompromised or have antibiotic-resistant infections.
✕Less likely to help
Patients with infections caused by other types of bacteria or those who are not immunocompromised may not benefit from this research.
What this research studies
This research investigates how the bacterium Pseudomonas aeruginosa, a common cause of serious infections, manages to survive despite the host's immune response that produces nitric oxide (NO) to eliminate it. The study focuses on the mechanisms of nitric oxide detoxification and reactivity within the bacteria, exploring how it interacts with the immune system and the environment. By examining genetic mutants of P. aeruginosa, researchers aim to identify specific pathways that allow the bacteria to resist the effects of NO, which could lead to new therapeutic strategies. The findings may provide insights into the development of treatments for infections caused by antibiotic-resistant bacteria.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from infections caused by antibiotic-resistant Pseudomonas aeruginosa.
How similar studies have gone: Other research has shown success in understanding bacterial resistance mechanisms, making this approach promising but still requiring further exploration.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Lonergan, Zachery — Rutgers, the State Univ of N.j.
- Study coordinator: Lonergan, Zachery
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.