Understanding how Pseudomonas aeruginosa survives in low-oxygen environments
Official title: Guided multiplex analysis of microoxic fitness factors in P. aeruginosa
Funded at Dartmouth College · NIH-10851894 · Data updated 2026-11-12
This study is looking at how a tough germ called Pseudomonas aeruginosa survives in low-oxygen situations, which can help us find new ways to prevent and treat infections caused by it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $245,938 |
| NIH project number | 5R21AI174132-02 |
| Project ID | NIH-10851894 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by Pseudomonas aeruginosa, particularly those with conditions like cystic fibrosis or bronchiectasis.
✕Less likely to help
Patients with infections caused by other pathogens or those not affected by Pseudomonas aeruginosa may not benefit from this research.
What this research studies
This research investigates the survival mechanisms of Pseudomonas aeruginosa, a common and drug-resistant pathogen, particularly in low-oxygen conditions. By analyzing existing genetic data, the study aims to identify specific genes that help this bacterium thrive in challenging environments, which could lead to new strategies for preventing and treating infections. The research utilizes advanced machine learning techniques to interpret large datasets of gene expression, enhancing our understanding of how this pathogen behaves in various infection contexts.
Why it matters
Potential benefit: If successful, this research could lead to innovative methods for preventing and treating infections caused by drug-resistant Pseudomonas aeruginosa.
How similar studies have gone: Previous research has successfully utilized similar approaches to understand bacterial behavior and resistance mechanisms, indicating potential for impactful findings in this study.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Hogan, Deborah a — Dartmouth College
- Study coordinator: Hogan, Deborah a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.