Understanding how Pseudomonas aeruginosa survives antibiotic treatment
Official title: Molecular Mechanisms of Pseudomonas aeruginosa Antibiotic Persistence in Monocultures and Microbial Communities
Funded at University of Connecticut Sch of Med/dnt · NIH-10749974 · Data updated 2026-11-12
This study looks at how a common germ called Pseudomonas aeruginosa can survive antibiotics even though it doesn't have the usual resistance genes, and it aims to help doctors find better ways to treat infections caused by this tough bacteria.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2023 |
| Award (this year) | $44,481 |
| NIH project number | 1F30DE032598-01A1 |
| Project ID | NIH-10749974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic or recurrent infections caused by Pseudomonas aeruginosa.
✕Less likely to help
Patients with infections caused by bacteria other than Pseudomonas aeruginosa may not benefit from this research.
What this research studies
This research investigates the mechanisms by which Pseudomonas aeruginosa, a common opportunistic pathogen, can survive antibiotic treatment despite not having known resistance genes. The study focuses on understanding the cellular responses that allow these bacteria to persist and potentially lead to chronic infections. By examining how these bacteria interact with other microbes, such as Staphylococcus aureus, the research aims to uncover factors that contribute to their survival. Patients may benefit from insights gained into how to better treat infections caused by these resilient bacteria.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for infections caused by antibiotic-resistant bacteria.
How similar studies have gone: Previous research has shown promising results in understanding bacterial persistence, but this specific approach to studying Pseudomonas aeruginosa is relatively novel.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Hare, Patricia Jin — University of Connecticut Sch of Med/dnt
- Study coordinator: Hare, Patricia Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.