Understanding how *Pseudomonas aeruginosa* bacteria survive in serious infections
Biological mechanisms and consequences of efficient extracellular electron transfer in Pseudomonas aeruginosa
This project aims to understand how *Pseudomonas aeruginosa* bacteria survive and resist antibiotics in infections like burns, wounds, and cystic fibrosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-11112455 on NIH RePORTER |
What this research studies
*Pseudomonas aeruginosa* is a common bacterium that causes serious infections in people with burns, wounds, and cystic fibrosis. These bacteria often form protective layers called biofilms, which make them very hard to treat with antibiotics. This research looks at a colorful substance called pyocyanin that *P. aeruginosa* makes, which helps the bacteria survive and form these resistant biofilms. By learning how pyocyanin and other factors help the bacteria thrive, we hope to find new ways to fight these stubborn infections.
Who could benefit from this research
Good fit: This foundational research is relevant to patients experiencing acute or chronic infections caused by *Pseudomonas aeruginosa*, such as those with burn injuries, chronic wounds, or cystic fibrosis.
Not a fit: Patients whose infections are not caused by *Pseudomonas aeruginosa* would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for treating *Pseudomonas aeruginosa* infections, especially those resistant to current antibiotics.
How similar studies have performed: This work builds upon recent findings about how *P. aeruginosa* uses extracellular DNA to promote survival within biofilms, exploring novel aspects of its biological mechanisms.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Newman, Dianne K — California Institute of Technology
- Study coordinator: Newman, Dianne K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.