Understanding how protons and electrons work together in biological processes
Coupled Protons and Electrons in Biological Systems
This study is looking at how tiny particles called protons and electrons work together in our cells to help with important processes like breathing and making DNA, and the findings could help improve treatments for conditions related to how our bodies use energy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-10991351 on NIH RePORTER |
What this research studies
This research investigates the critical role of protons and electrons in various biological processes such as cellular respiration and DNA biosynthesis. By developing a multiscale modeling approach, the team aims to simulate the complex interactions of protons and electrons, which are essential for understanding how these processes function at a molecular level. The research utilizes advanced computational methods, including quantum chemistry and molecular dynamics, to analyze the behavior of these particles in biological systems. Patients may benefit from insights gained that could lead to improved treatments for conditions related to cellular metabolism.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with metabolic disorders or conditions affecting cellular respiration.
Not a fit: Patients with unrelated health conditions that do not involve metabolic processes may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular processes, potentially leading to new therapies for metabolic disorders.
How similar studies have performed: Previous research has shown promise in understanding proton-coupled electron transfer in simpler systems, but this approach aims to tackle more complex biological processes, making it a novel endeavor.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Hammes-Schiffer, Sharon — Princeton University
- Study coordinator: Hammes-Schiffer, Sharon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.