Understanding how proteoglycans affect heart valve development and disease
Proteoglycan Metabolism During Cardiac Valve Development and Disease
This study is looking at how certain proteins in the heart can affect the aortic valve, especially for people with Bicuspid Aortic Valve, to help find better ways to understand and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10994139 on NIH RePORTER |
What this research studies
This research investigates the role of proteoglycans in the development and dysfunction of the aortic valve, particularly focusing on a condition known as Bicuspid Aortic Valve (BAV). Researchers are studying how the accumulation of specific proteoglycans, which are essential components of the extracellular matrix, contributes to heart valve abnormalities and related complications. By using genetically modified mouse models, the team aims to uncover the molecular mechanisms behind these conditions, which could lead to better understanding and treatment options for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Bicuspid Aortic Valve or related aortic valve disorders.
Not a fit: Patients without any heart valve abnormalities or those with other unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients with aortic valve diseases.
How similar studies have performed: Previous research has shown promising results in understanding heart valve development and disease mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Kern, Christine Bruins — Medical University of South Carolina
- Study coordinator: Kern, Christine Bruins
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.