Understanding how proteins work in the Hedgehog signaling pathway
Protein dynamics underlying cilium-dependent Hedgehog signaling
This study is looking at how a special part of our cells, called the primary cilium, helps control important signals that affect growth and health, with the hope of finding better treatments for certain birth defects and cancers related to these signals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11099312 on NIH RePORTER |
What this research studies
This research investigates the Hedgehog signaling pathway, which is crucial for both embryonic development and maintaining healthy tissues in adults. It focuses on the role of a cellular structure called the primary cilium and how proteins interact within this pathway to influence cell signaling. By using advanced imaging techniques and biochemical assays, the researchers aim to uncover the molecular mechanisms that govern these interactions, which could lead to a better understanding of related birth defects and cancers. The ultimate goal is to provide insights that could improve therapeutic strategies for conditions linked to Hedgehog signaling errors.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with congenital birth defects or cancers such as basal cell carcinoma that are linked to Hedgehog signaling abnormalities.
Not a fit: Patients with conditions unrelated to Hedgehog signaling or those who do not have any of the associated birth defects or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for birth defects and cancers associated with Hedgehog signaling dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding cellular signaling pathways, making this approach both relevant and potentially impactful.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Subramanian, Radhika — Massachusetts General Hospital
- Study coordinator: Subramanian, Radhika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.