Understanding how proteins work in the Hedgehog signaling pathway
Protein dynamics underlying cilium-dependent Hedgehog signaling
This study is looking at how a special part of our cells, called the primary cilium, helps control important signals that affect growth and health, which could lead to better understanding of certain birth defects and cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10895335 on NIH RePORTER |
What this research studies
This research investigates the Hedgehog signaling pathway, which is crucial for both embryonic development and maintaining healthy tissues in adults. It focuses on the role of a cellular structure called the primary cilium and how proteins interact within this pathway to influence cell signaling. By using advanced imaging techniques and biochemical assays, the research aims to clarify the molecular mechanisms that govern these protein interactions and their effects on cell function. This knowledge could help in understanding various birth defects and cancers linked to errors in this signaling pathway.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to Hedgehog signaling abnormalities, such as basal cell carcinoma or specific birth defects.
Not a fit: Patients with conditions unrelated to Hedgehog signaling or those who do not have any genetic predispositions linked to this pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of certain birth defects and cancers, potentially guiding the development of targeted therapies.
How similar studies have performed: Previous research has shown success in understanding similar signaling pathways, indicating that this approach has the potential for meaningful discoveries.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Subramanian, Radhika — Massachusetts General Hospital
- Study coordinator: Subramanian, Radhika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.