Understanding how proteins transport materials in cells
Biochemical and cellular functions of Karyopherins
This study is looking at how certain proteins help move important materials in and out of cell nuclei, which could help us understand their role in health and diseases like cancer, ultimately aiming to find ways to keep our cells working properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11084447 on NIH RePORTER |
What this research studies
This research investigates the role of Karyopherin-β proteins in recognizing their binding partners and facilitating the transport of materials between the nucleus and cytoplasm of cells. By studying both human and yeast proteins, the research aims to uncover how these proteins regulate cellular functions and contribute to health and disease. The team will explore the mechanisms of nuclear transport and the chaperone functions of these proteins, which may help prevent cellular dysfunction. Patients may benefit from insights gained about how these processes are altered in diseases like cancer.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders or cancers that may involve disruptions in cellular transport mechanisms.
Not a fit: Patients with conditions unrelated to cellular transport or those not affected by genetic mutations may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cellular transport dysfunction, including various cancers.
How similar studies have performed: Previous research has shown success in understanding cellular transport mechanisms, suggesting that this approach may yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Chook, Yuh Min — Ut Southwestern Medical Center
- Study coordinator: Chook, Yuh Min
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.