Understanding how proteins transport ions and maintain DNA integrity
Official title: Molecular mechanisms of protein function
Funded at Sloan-Kettering Inst Can Research · NIH-11011871 · Data updated 2026-11-12
This study is looking at how certain proteins help move ions in and out of cells and keep our DNA healthy, which is important for preventing diseases like cancer, and it aims to find new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $534,160 |
| NIH project number | 1R35GM156616-01 |
| Project ID | NIH-11011871 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to ion transport dysregulation or genomic instability, such as certain types of cancer.
✕Less likely to help
Patients with conditions unrelated to ion transport or genomic integrity may not receive any benefit from this research.
What this research studies
This research investigates the molecular mechanisms of proteins that facilitate the transport of ions across cell membranes and ensure the integrity of DNA through replication and repair. By employing a collaborative approach that includes high-resolution structure determination, electrophysiology, and computational analysis, the research aims to uncover how these proteins function and how their dysregulation can lead to diseases such as cancer. The study focuses on specific ion transport proteins and their roles in cellular processes, which could provide insights into potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases related to ion transport and genomic integrity, including various cancers.
How similar studies have gone: Previous research has shown success in understanding protein functions related to ion transport and genomic integrity, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Hite, Richard Kevin — Sloan-Kettering Inst Can Research
- Study coordinator: Hite, Richard Kevin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.