Understanding how proteins transport ions across cell membranes
Molecular Mechanisms of Channels and Transporters
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11075210
This study is looking at how certain proteins help move important ions in and out of cells, which could lead to new treatments for conditions related to ion transport, and it's for anyone interested in understanding how our bodies manage these tiny but crucial processes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11075210 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms by which proteins, specifically ion channels and transporters, move ions across biological membranes. By using advanced techniques like NMR spectroscopy, the team aims to uncover how these proteins change structure to regulate ion flow and actively pump substances. The research includes various projects that explore topics such as drug recognition, temperature sensing, and the regulation of protein activity through small interactions. Patients may benefit from insights gained into how these proteins function, potentially leading to new treatments for conditions related to ion transport.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to ion transport disorders, such as cystic fibrosis or certain cardiac arrhythmias.
Not a fit: Patients with conditions unrelated to ion transport mechanisms may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for diseases caused by dysfunctional ion transport mechanisms.
How similar studies have performed: Other research has shown success in understanding ion transport mechanisms, indicating that this approach is built on a foundation of prior findings.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HENZLER-WILDMAN, KATHERINE ANNE — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: HENZLER-WILDMAN, KATHERINE ANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.