Understanding how proteins stay healthy in our cells
Molecular Chaperone-mediated Regulated of Cell Metabolism
['FUNDING_OTHER'] · UNIVERSITY OF IOWA · NIH-11123284
This research explores how special helper proteins called chaperones keep our cells working properly by managing other proteins, which is important for preventing diseases like neurological disorders and cancers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11123284 on ClinicalTrials.gov |
What this research studies
Our bodies constantly face challenges to keep proteins in good shape, and this project looks at how cells use a network of helper proteins, called molecular chaperones, to make sure proteins fold correctly and don't clump together. When proteins misbehave and aggregate, it can lead to serious conditions like neurological diseases and cancers. We are learning that these chaperones also play a role in how cells use energy and build necessary molecules for survival. This work uses advanced microscopy and other tools to uncover how chaperones recognize and act on these important enzymes.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but future studies building on these findings could benefit individuals with neurological diseases or certain cancers.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this research could lead to new ways to prevent or treat neurological diseases and cancers by targeting how cells manage their proteins and metabolism.
How similar studies have performed: While the specific mechanisms of chaperone regulation on metabolic enzymes are still being uncovered, the general importance of protein chaperones in disease is well-established.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEDLEY, ANTHONY M — UNIVERSITY OF IOWA
- Study coordinator: PEDLEY, ANTHONY M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.