Understanding how proteins regulate salt transport in the kidneys
Official title: Regulation of NKCC2 and renal NaCl transport by protein-protein interactions
Funded at Wayne State University · NIH-11004671 · Data updated 2026-11-12
This study is looking at how certain proteins in the kidneys work with a transporter that helps control salt levels and blood pressure, with the goal of finding new ways to help people with high blood pressure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | January 20, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $484,984 |
| NIH project number | 5R01DK131114-03 |
| Project ID | NIH-11004671 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with salt-sensitive hypertension or related kidney issues.
✕Less likely to help
Patients with normal blood pressure and no kidney-related conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms by which specific proteins interact with the NKCC2 transporter in the kidneys, which is crucial for maintaining salt balance and regulating blood pressure. By studying how these proteins affect the absorption of sodium and chloride in the thick ascending limb of the loop of Henle, the research aims to uncover potential targets for treating conditions like hypertension. The approach includes using animal models and advanced proteomics techniques to identify and analyze protein interactions that influence kidney function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for hypertension and related kidney disorders by targeting the proteins that regulate salt transport.
How similar studies have gone: Previous research has shown success in understanding protein interactions in kidney function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Ortiz, Pablo a. — Wayne State University
- Study coordinator: Ortiz, Pablo a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.