Understanding how proteins regulate kidney acidification.
Defining protein:protein interactions for the regulation of renal V-ATPase function: role in expression, assembly and trafficking.
This study is looking at how certain proteins in the kidneys help control the balance of acids in the body, which is important for keeping you healthy, and it hopes to find new ways to treat conditions where this balance goes wrong.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10670311 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms by which specific proteins, Ncoa7 and Dmxl1, interact with the V-ATPase enzyme in the kidneys to regulate proton secretion and maintain acid/base balance in the body. By studying these interactions in both animal models and cell cultures, the researchers aim to uncover how these proteins influence the expression and function of V-ATPase. The ultimate goal is to develop new therapeutic strategies to correct acidification processes that are disrupted in various diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with renal tubular acidosis or other conditions affecting acid/base balance.
Not a fit: Patients with unrelated kidney conditions or those not experiencing acid/base imbalances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to acid/base imbalance in the kidneys and other organs.
How similar studies have performed: Previous research has shown promising results in understanding protein interactions related to V-ATPase function, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Brown, Dennis — Massachusetts General Hospital
- Study coordinator: Brown, Dennis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.