Understanding how proteins regulate gene expression in cells
Official title: Integrated frameworks for single-cell epigenomics based transcriptional regulatory networks
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-10916376 · Data updated 2026-11-12
This study is looking at how certain proteins help control gene activity in different cells, which could lead to better ways to understand and treat diseases that happen when gene expression goes wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $415,081 |
| NIH project number | 5R35GM150616-02 |
| Project ID | NIH-10916376 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to gene expression and cellular differentiation.
✕Less likely to help
Patients with conditions unrelated to transcriptional regulation or gene expression may not benefit from this research.
What this research studies
This research investigates the role of transcription factors, which are proteins that control the expression of genes in various cell types. By developing advanced models that capture the complex networks of these regulatory relationships, the research aims to provide insights into how cells differentiate and function. The approach involves analyzing changes in chromatin architecture, which is crucial for understanding gene regulation dynamics. Patients may benefit from this research as it could lead to better understanding and treatment of diseases caused by dysregulation of gene expression.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating diseases linked to gene expression dysregulation.
How similar studies have gone: Other research has shown success in understanding transcriptional regulation through similar modeling approaches, indicating a promising avenue for further exploration.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Uzun, Yasin — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Uzun, Yasin
Related research
Other NIH-funded projects on the same topics.
-
Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure
A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.
-
Understanding the STIM/Orai Calcium Signaling Pathway in Cancer
Researchers are studying how STIM and Orai proteins control calcium signals inside cells and how this affects cancer-related growth and remodeling, with hopes to find ways to influence these signals for better treatments.
-
Understanding how some Amish communities maintain high birth rates in modern times
A project will build a large, time-sensitive dataset to understand why Amish families keep having many children, even as broader society has much lower birth rates.
-
Scoliosis and neurosurgical factors in myelomeningocele: a clinic registry study
This project uses registry data from Penn State’s Spina Bifida Clinic to understand how brain and spine-related issues influence when and why scoliosis surgery is needed in people with myelomeningocele.
-
Understanding how damaged stomach cells revert to a repair state to prevent cancer
Researchers are studying how certain stomach cells re-enter the cell cycle to aid tissue repair, and how this process might lead to metaplasia or cancer if it goes wrong.
-
Aging, cell aging, and how MCPyV causes Merkel cell carcinoma
Aging and aging-related changes in skin cells may help a common virus (MCPyV) persist and potentially lead to a rare skin cancer in people with weaker immune systems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.