Understanding how proteins regulate gene expression in cells
Integrated frameworks for single-cell epigenomics based transcriptional regulatory networks
['FUNDING_OTHER'] · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · NIH-10916376
This study is looking at how certain proteins help control gene activity in different cells, which could lead to better ways to understand and treat diseases that happen when gene expression goes wrong.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIV HERSHEY MED CTR (nih funded) |
| Locations | 1 site (HERSHEY, UNITED STATES) |
| Trial ID | NIH-10916376 on ClinicalTrials.gov |
What this research studies
This research investigates the role of transcription factors, which are proteins that control the expression of genes in various cell types. By developing advanced models that capture the complex networks of these regulatory relationships, the research aims to provide insights into how cells differentiate and function. The approach involves analyzing changes in chromatin architecture, which is crucial for understanding gene regulation dynamics. Patients may benefit from this research as it could lead to better understanding and treatment of diseases caused by dysregulation of gene expression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene expression and cellular differentiation.
Not a fit: Patients with conditions unrelated to transcriptional regulation or gene expression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating diseases linked to gene expression dysregulation.
How similar studies have performed: Other research has shown success in understanding transcriptional regulation through similar modeling approaches, indicating a promising avenue for further exploration.
Where this research is happening
HERSHEY, UNITED STATES
- PENNSYLVANIA STATE UNIV HERSHEY MED CTR — HERSHEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UZUN, YASIN — PENNSYLVANIA STATE UNIV HERSHEY MED CTR
- Study coordinator: UZUN, YASIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.