Understanding how proteins regulate DNA repair and aging
Novel pathways that regulate DNA double-strand break repair events in mammalian cells
This study is looking at how certain proteins that help organize our DNA can affect how our cells fix damage to DNA and how we age, with the hope of finding new ways to keep our DNA healthy and possibly help us live longer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11011343 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which proteins associated with DNA, known as chromatin, influence the repair of DNA damage and the aging process. By utilizing advanced techniques in biochemistry, structural biology, and molecular genetics, the team aims to uncover how chromatin is reorganized during critical cellular processes, including DNA repair. The research also explores innovative methods, such as CRISPR/Cas9 technology, to identify new factors that control DNA repair pathways, which could have implications for maintaining genomic stability and extending lifespan.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological processes of aging and those with conditions related to genomic instability.
Not a fit: Patients with acute DNA damage that requires immediate clinical intervention may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing DNA repair mechanisms, potentially improving health outcomes related to aging and genetic stability.
How similar studies have performed: Previous research has shown promising results in understanding chromatin's role in DNA repair, suggesting that this approach could yield significant insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Tyler, Jessica K — Weill Medical Coll of Cornell Univ
- Study coordinator: Tyler, Jessica K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.