Understanding how proteins regulate cell division
Official title: Ubiquitin-mediated regulation of kinetochore assembly and function
Funded at Fred Hutchinson Cancer Center · NIH-10997121 · Data updated 2026-11-12
This study is looking at how a tiny protein called ubiquitin helps cells divide correctly, using yeast to understand how different proteins work together during this process, which could help us learn more about diseases like cancer that happen when cell division goes wrong.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $76,828 |
| NIH project number | 1F32GM156071-01 |
| Project ID | NIH-10997121 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to aneuploidy or other genetic disorders linked to cell division errors.
✕Less likely to help
Patients with conditions unrelated to cell division or genetic regulation may not benefit from this research.
What this research studies
This research investigates the role of ubiquitin, a small protein, in the assembly and function of kinetochores, which are essential for accurate cell division. By studying the budding yeast, the researchers aim to create a detailed map of how specific proteins interact during the cell cycle. The approach combines advanced techniques in proteomics, yeast genetics, and biochemistry to uncover the mechanisms that ensure proper genome segregation. This knowledge could provide insights into the causes of diseases related to cell division errors, such as cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases caused by errors in cell division.
How similar studies have gone: Previous research has shown success in understanding protein regulation in cell division, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Frank, Anderson Ross — Fred Hutchinson Cancer Center
- Study coordinator: Frank, Anderson Ross
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.