Understanding how proteins regulate actin filament dynamics
Multicomponent mechanochemical regulation of actin filament end dynamics
This study is looking at how certain proteins work together to control the building and breaking down of actin filaments, which are important for how our cells move and divide, and it could help people with conditions like Alzheimer's and ALS by providing new insights into these processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11129903 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between proteins that control the growth and disassembly of actin filaments, which are crucial for various cellular processes like cell movement and division. By examining how these proteins work together, the research aims to uncover new insights into the biochemical and mechanical signals that influence actin dynamics. Patients with conditions like Alzheimer's disease and ALS may benefit from a better understanding of these cellular processes, as they are linked to neurodegenerative diseases. The research employs advanced microscopic techniques to visualize these interactions in real-time.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with Alzheimer's disease or amyotrophic lateral sclerosis (ALS).
Not a fit: Patients with conditions unrelated to actin dynamics or neurodegeneration may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodegenerative diseases by targeting actin dynamics.
How similar studies have performed: Other research has shown promising results in understanding actin dynamics, but this approach aims to explore novel interactions that have not been extensively studied.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Shekhar, Shashank — Emory University
- Study coordinator: Shekhar, Shashank
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.