Understanding how proteins recognize molecules and function
Mapping Fitness & Free Energy Landscapes of Proteins
['FUNDING_OTHER'] · TEMPLE UNIV OF THE COMMONWEALTH · NIH-10842535
This study is looking at how certain proteins, especially those involved in diseases like cancer, work and change shape, which could help create better treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEMPLE UNIV OF THE COMMONWEALTH (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10842535 on ClinicalTrials.gov |
What this research studies
This research investigates the complex ways proteins interact with other molecules, focusing on their structural and functional characteristics. By using advanced techniques like machine learning and molecular dynamics, the team aims to map the fitness landscapes of proteins, particularly kinases, which play a crucial role in various diseases. The study will explore how these proteins transition between active and inactive states and how they bind to different substrates, which is essential for developing targeted therapies. Patients may benefit from insights gained in designing more effective treatments for conditions like cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to kinase activity, such as certain types of cancer.
Not a fit: Patients with conditions unrelated to protein function or kinase activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more targeted and effective cancer therapies.
How similar studies have performed: Other research has shown success in using similar approaches to understand protein interactions and develop targeted therapies.
Where this research is happening
PHILADELPHIA, UNITED STATES
- TEMPLE UNIV OF THE COMMONWEALTH — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEVY, RONALD — TEMPLE UNIV OF THE COMMONWEALTH
- Study coordinator: LEVY, RONALD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus