Understanding how proteins organize in the cell's genetic material
Modulation and functional characterization of protein condensation in chromatin organization
This study is looking at how specific proteins help organize our genetic material, which could help us understand how cells develop and function, and it might lead to new treatments for different health conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10901997 on NIH RePORTER |
What this research studies
This research investigates how certain proteins can condense and organize chromatin, which is the material that makes up our genes. By developing specialized tools, the researchers aim to control the ability of these proteins to phase-separate, allowing them to observe how this affects gene expression and the fate of cells. Patients may benefit from insights gained about stem cell differentiation and gene regulation, which could lead to new treatments for various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or those interested in advancements in stem cell therapies.
Not a fit: Patients with conditions unrelated to chromatin organization or stem cell function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve stem cell differentiation and gene regulation, potentially benefiting patients with genetic disorders or conditions related to stem cell function.
How similar studies have performed: Other research has shown promising results in understanding protein phase separation and its implications for gene regulation, indicating that this approach has potential for success.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Huang, Bo — University of California, San Francisco
- Study coordinator: Huang, Bo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.