Understanding how proteins modify DNA packaging to regulate gene expression
Structural studies of chromatin complexes
['FUNDING_OTHER'] · PENNSYLVANIA STATE UNIVERSITY, THE · NIH-11061915
This study is looking at how certain proteins change the way DNA is packed in our cells, which helps control how genes work, and it could help us find new ways to treat diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIVERSITY, THE (nih funded) |
| Locations | 1 site (UNIVERSITY PARK, UNITED STATES) |
| Trial ID | NIH-11061915 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which proteins modify the structure of DNA packaging, known as nucleosomes, to regulate gene expression in cells. By using advanced techniques like cryo-electron microscopy, the team aims to visualize these protein interactions and understand how they influence gene activity. The research combines structural models with biochemical assays to test hypotheses about how these modifications occur and their implications for diseases such as cancer. This work could lead to new insights into gene regulation and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancers or other diseases linked to epigenetic changes.
Not a fit: Patients with conditions unrelated to epigenetic modifications or those not affected by cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies targeting epigenetic mechanisms involved in cancer and other diseases.
How similar studies have performed: Previous research has shown success in understanding epigenetic mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
UNIVERSITY PARK, UNITED STATES
- PENNSYLVANIA STATE UNIVERSITY, THE — UNIVERSITY PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAN, SONG — PENNSYLVANIA STATE UNIVERSITY, THE
- Study coordinator: TAN, SONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers