Understanding how proteins manage iron levels in the body
Official title: Deciphering the Structures and Mechanisms of Metalloproteins Involved in Human Iron Homeostasis
Funded at Purdue University · NIH-11110506 · Data updated 2026-11-12
This study is looking at special proteins that help keep iron levels balanced in our bodies, which could lead to new treatments for health issues related to iron, like certain brain diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | June 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $379,755 |
| NIH project number | 5R35GM155016-02 |
| Project ID | NIH-11110506 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodegenerative diseases or conditions related to iron metabolism.
✕Less likely to help
Patients without any iron metabolism disorders or neurodegenerative diseases may not benefit from this research.
What this research studies
This research investigates the structures and functions of metalloproteins that play a crucial role in maintaining iron balance in the human body. By exploring how iron is transported and regulated at the cellular level, the study aims to uncover the molecular mechanisms that can lead to health complications when iron levels are imbalanced. The research employs a multidisciplinary approach, combining techniques from biochemistry and molecular biology to analyze these proteins and their interactions. Patients may benefit from insights gained that could inform new treatments for conditions related to iron dysregulation, including neurodegenerative diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for diseases associated with iron imbalance, such as Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding iron's role in neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Tian, Shiliang — Purdue University
- Study coordinator: Tian, Shiliang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.