Understanding how proteins maintain their correct structure and function
Translational quality control by trans-editing domains
['FUNDING_OTHER'] · OHIO STATE UNIVERSITY · NIH-11100083
This study is looking at how certain proteins help make sure that building blocks for proteins are matched correctly, which is really important for keeping our cells healthy, and it aims to learn more about how these proteins work, especially in living things like plants and animals.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11100083 on ClinicalTrials.gov |
What this research studies
This research investigates the role of aminoacyl-tRNA synthetases (ARSs) in ensuring that amino acids are accurately attached to their corresponding tRNA, which is crucial for protein synthesis. It explores how errors in this process can lead to toxic effects in cells and examines the quality control mechanisms that are influenced by specific cellular needs and environmental conditions. The study aims to uncover the functions of a family of proteins known as the INS superfamily, which are believed to play a significant role in maintaining the accuracy of protein translation. By utilizing advanced techniques to analyze these proteins, the research seeks to fill existing knowledge gaps regarding their physiological roles, particularly in eukaryotic organisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein misfolding or translation errors, such as certain genetic disorders or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein synthesis or those who do not exhibit issues with protein folding may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of diseases caused by protein misfolding and mistranslation.
How similar studies have performed: Previous research has shown promising results in understanding the roles of aminoacyl-tRNA synthetases and their proofreading functions, suggesting that this approach has potential for significant advancements.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUSIER-FORSYTH, KARIN M — OHIO STATE UNIVERSITY
- Study coordinator: MUSIER-FORSYTH, KARIN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.