Understanding how proteins maintain genome stability
Mechanisms of Genome Stability
['FUNDING_OTHER'] · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · NIH-10772342
This study is looking at how certain proteins help our cells copy DNA correctly and fix any damage, which is really important for keeping our genes healthy and preventing diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN (nih funded) |
| Locations | 1 site (CHAMPAIGN, UNITED STATES) |
| Trial ID | NIH-10772342 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which specific proteins, known as the Origin Recognition Complex (ORC) and its associated factors, help ensure the accurate duplication of our DNA and respond to DNA damage. By studying the roles of these proteins in cell growth and division, the research aims to uncover how they contribute to maintaining genomic stability, which is crucial for preventing diseases like cancer. The approach involves detailed biochemical and cellular analyses to explore how these proteins function during different phases of the cell cycle and in response to genotoxic stress.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those diagnosed with conditions related to genomic instability.
Not a fit: Patients with stable genomes and no history of genetic disorders or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers by enhancing our understanding of genome stability.
How similar studies have performed: Previous research has shown success in understanding the roles of ORC proteins in other contexts, indicating that this approach has a foundation in established science.
Where this research is happening
CHAMPAIGN, UNITED STATES
- UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN — CHAMPAIGN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PRASANTH, SUPRIYA G — UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- Study coordinator: PRASANTH, SUPRIYA G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers