Understanding how proteins maintain genome stability
Official title: Mechanisms of Genome Stability
Funded at University of Illinois at Urbana-Champaign · NIH-10772342 · Data updated 2026-11-12
This study is looking at how certain proteins help our cells copy DNA correctly and fix any damage, which is really important for keeping our genes healthy and preventing diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project start | August 16, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $375,365 |
| NIH project number | 1R35GM152450-01 |
| Project ID | NIH-10772342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of cancer or those diagnosed with conditions related to genomic instability.
✕Less likely to help
Patients with stable genomes and no history of genetic disorders or cancers may not benefit from this research.
What this research studies
This research investigates the mechanisms by which specific proteins, known as the Origin Recognition Complex (ORC) and its associated factors, help ensure the accurate duplication of our DNA and respond to DNA damage. By studying the roles of these proteins in cell growth and division, the research aims to uncover how they contribute to maintaining genomic stability, which is crucial for preventing diseases like cancer. The approach involves detailed biochemical and cellular analyses to explore how these proteins function during different phases of the cell cycle and in response to genotoxic stress.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers by enhancing our understanding of genome stability.
How similar studies have gone: Previous research has shown success in understanding the roles of ORC proteins in other contexts, indicating that this approach has a foundation in established science.
Where this research is happening
-
University of Illinois at Urbana-Champaign
Champaign, United States Active
Researchers
- Principal investigator: Prasanth, Supriya G — University of Illinois at Urbana-Champaign
- Study coordinator: Prasanth, Supriya G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.