Understanding how proteins involved in heart cell adhesion affect arrhythmogenic cardiomyopathy
Characterizing regulatory mechanisms of desmosomal protein expression in arrhythmogenic cardiomyopathy
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11031314
This study is looking at how certain proteins that help heart cells stick together are affected in arrhythmogenic cardiomyopathy (ACM), with the hope of finding new ways to help people with this heart condition feel better.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11031314 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which desmosomal proteins, crucial for heart cell adhesion, are regulated in arrhythmogenic cardiomyopathy (ACM). The study will utilize molecular and theoretical approaches to analyze changes in gene expression and protein levels associated with the disease. By employing human induced pluripotent stem cells and mouse models, the research aims to identify potential therapeutic targets that could improve patient care for those affected by ACM. The goal is to better understand how disruptions in these proteins contribute to the progression of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with arrhythmogenic cardiomyopathy or those with a family history of the condition.
Not a fit: Patients with other forms of heart disease unrelated to desmosomal protein dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from arrhythmogenic cardiomyopathy.
How similar studies have performed: Previous research has shown promise in understanding the role of desmosomal proteins in heart diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ELLIS, MATTHEW W — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: ELLIS, MATTHEW W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.