Understanding how proteins involved in heart cell adhesion affect arrhythmogenic cardiomyopathy
Official title: Characterizing regulatory mechanisms of desmosomal protein expression in arrhythmogenic cardiomyopathy
Funded at University of California, San Diego · NIH-11031314 · Data updated 2026-11-12
This study is looking at how certain proteins that help heart cells stick together are affected in arrhythmogenic cardiomyopathy (ACM), with the hope of finding new ways to help people with this heart condition feel better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $77,284 |
| NIH project number | 5F32HL172624-02 |
| Project ID | NIH-11031314 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with arrhythmogenic cardiomyopathy or those with a family history of the condition.
✕Less likely to help
Patients with other forms of heart disease unrelated to desmosomal protein dysfunction may not benefit from this research.
What this research studies
This research investigates the mechanisms by which desmosomal proteins, crucial for heart cell adhesion, are regulated in arrhythmogenic cardiomyopathy (ACM). The study will utilize molecular and theoretical approaches to analyze changes in gene expression and protein levels associated with the disease. By employing human induced pluripotent stem cells and mouse models, the research aims to identify potential therapeutic targets that could improve patient care for those affected by ACM. The goal is to better understand how disruptions in these proteins contribute to the progression of the disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from arrhythmogenic cardiomyopathy.
How similar studies have gone: Previous research has shown promise in understanding the role of desmosomal proteins in heart diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Ellis, Matthew W — University of California, San Diego
- Study coordinator: Ellis, Matthew W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.