Understanding how proteins involved in DNA repair are regulated and localized
Official title: Regulation and Localization of Mismatch Repair Proteins
Funded at Xavier University of Louisiana · NIH-11089593 · Data updated 2026-11-12
This study looks at how certain proteins help fix mistakes in DNA, using yeast to learn more about how these proteins work together, which could help us understand better ways to prevent cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Xavier University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | August 1, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $187,500 |
| NIH project number | 5R16GM146801-04 |
| Project ID | NIH-11089593 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of Lynch Syndrome or early onset cancers related to DNA mismatch repair deficiencies.
✕Less likely to help
Patients with cancers unrelated to DNA mismatch repair or those without hereditary cancer syndromes may not benefit from this research.
What this research studies
This research investigates the regulation and localization of mismatch repair proteins, which are crucial for maintaining the integrity of DNA. By using the yeast model organism, the study aims to understand how specific proteins, such as Gcn5 and Not4, influence the stability and function of the mismatch repair complex MutSα. The research employs various biochemical assays to analyze the interactions and modifications of these proteins during DNA replication. Insights gained from this research could help elucidate the mechanisms behind DNA repair processes that are vital for preventing cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of DNA repair mechanisms, potentially informing new strategies for cancer prevention and treatment.
How similar studies have gone: Previous research has shown success in understanding DNA repair mechanisms in model organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Xavier University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Haye, Joanna E — Xavier University of Louisiana
- Study coordinator: Haye, Joanna E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.