Understanding how proteins interact with nucleic acids in cells
Protein-nucleic acid interactions in basic cellular processes
['FUNDING_OTHER'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10841869
This study is looking at how bacteria protect themselves from viruses and fix their DNA when it gets damaged, which could help us find new treatments for infections and diseases related to DNA problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10841869 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between proteins and nucleic acids, focusing on bacterial defense systems and how cells manage DNA damage. It aims to uncover the mechanisms behind bacterial immunity to viruses and the role of specific DNA polymerases in repairing DNA lesions. By utilizing advanced techniques like cryo-electron microscopy, the research will explore the structures and functions of these critical biological components. Patients may benefit from insights gained in this research that could lead to new treatments for diseases related to DNA damage and bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to DNA damage or bacterial infections.
Not a fit: Patients with non-infectious diseases or those not affected by DNA damage may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing DNA damage and enhancing bacterial resistance to infections.
How similar studies have performed: Previous research has shown success in understanding protein-nucleic acid interactions, particularly in bacterial defense mechanisms, suggesting that this approach has a solid foundation.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AGGARWAL, ANEEL K. — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: AGGARWAL, ANEEL K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.