Understanding how proteins interact with drugs at a molecular level
High-resolution molecular recognition of ligands using solution X-ray scattering
This study is all about finding better ways to see how proteins and drugs work together, which can help scientists design more effective medications for people like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10455698 on NIH RePORTER |
What this research studies
This research focuses on improving our understanding of how proteins and drugs interact by developing new methods to visualize these interactions in high detail. It combines advanced techniques like X-ray scattering with existing structural data to overcome limitations in current methods that often fail to capture dynamic changes in protein-ligand complexes. By creating new algorithms, the research aims to provide clearer insights into the atomic-level interactions that are crucial for effective drug design and development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that require targeted drug therapies, particularly those involving protein-ligand interactions.
Not a fit: Patients with conditions that do not involve protein-ligand interactions or those who are not candidates for targeted therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective drugs by providing deeper insights into how drugs bind to their target proteins.
How similar studies have performed: Other research has shown success in using advanced structural methods to improve drug design, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Grant, Thomas D. — State University of New York at Buffalo
- Study coordinator: Grant, Thomas D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.