Understanding how proteins interact with DNA to regulate gene activity
Official title: Binding Kinetics in Transcription Activation and Repression
Funded at New York University School of Medicine · NIH-10922722 · Data updated 2026-11-12
This study is looking at how certain proteins that help control our genes stick to DNA, which is important for understanding how genes work and how changes in our genes can lead to diseases, so it could help patients learn more about their conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 6, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $630,559 |
| NIH project number | 5R01GM149835-02 |
| Project ID | NIH-10922722 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or those interested in the genetic basis of diseases.
✕Less likely to help
Patients with conditions unrelated to genetic regulation or those not affected by transcription factor dynamics may not benefit from this research.
What this research studies
This research investigates the binding dynamics of transcription factors (TFs) to DNA, which are crucial for gene regulation. By using advanced AI models and single-molecule tracking microscopy, the study aims to measure how often and how long these proteins bind to DNA, as well as their effects on gene expression. This approach will help clarify the mechanisms behind gene activation and repression, which are essential for understanding genetic diseases. Patients may benefit from insights gained about how genetic variations influence disease through these binding interactions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic diseases and the development of targeted therapies.
How similar studies have gone: Previous research has shown promising results in understanding transcription factor dynamics, but this specific approach using AI and single-molecule tracking is relatively novel.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Lionnet, Timothee — New York University School of Medicine
- Study coordinator: Lionnet, Timothee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.