Understanding how proteins interact with DNA to regulate gene activity
Binding Kinetics in Transcription Activation and Repression
This study is looking at how certain proteins that help control our genes stick to DNA, which is important for understanding how genes work and how changes in our genes can lead to diseases, so it could help patients learn more about their conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10922722 on NIH RePORTER |
What this research studies
This research investigates the binding dynamics of transcription factors (TFs) to DNA, which are crucial for gene regulation. By using advanced AI models and single-molecule tracking microscopy, the study aims to measure how often and how long these proteins bind to DNA, as well as their effects on gene expression. This approach will help clarify the mechanisms behind gene activation and repression, which are essential for understanding genetic diseases. Patients may benefit from insights gained about how genetic variations influence disease through these binding interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or those interested in the genetic basis of diseases.
Not a fit: Patients with conditions unrelated to genetic regulation or those not affected by transcription factor dynamics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic diseases and the development of targeted therapies.
How similar studies have performed: Previous research has shown promising results in understanding transcription factor dynamics, but this specific approach using AI and single-molecule tracking is relatively novel.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Lionnet, Timothee — New York University School of Medicine
- Study coordinator: Lionnet, Timothee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.