Understanding how proteins interact with DNA
Dynamics of DNA scanning and recognition by proteins
This study is looking at how certain proteins find and attach to DNA, which is important for controlling genes and keeping our genetic information safe, and it's designed for anyone interested in understanding the basics of how our cells work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-11015861 on NIH RePORTER |
What this research studies
This research investigates the dynamic interactions between DNA-binding proteins and DNA, which are essential for regulating gene expression and maintaining genomic integrity. By utilizing advanced nuclear magnetic resonance (NMR) techniques and other biophysical methods, the research team aims to explore how these proteins scan DNA and recognize their specific targets. The study focuses on the molecular and sub-molecular dynamics of these interactions, including how proteins navigate obstacles during their search for DNA targets. This comprehensive approach will enhance our understanding of the fundamental processes that underpin DNA-protein interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases linked to DNA-binding protein dysfunction.
Not a fit: Patients with conditions unrelated to DNA-binding protein interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of gene regulation and potential therapeutic targets for diseases caused by dysfunctional DNA-binding proteins.
How similar studies have performed: Previous research has shown promising results in understanding protein-DNA interactions using biophysical methods, indicating that this approach has potential for significant findings.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Iwahara, Junji — University of Texas Med Br Galveston
- Study coordinator: Iwahara, Junji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.